Clinical Oncology 2020 | Paris | France | Allied Conferences | Call for Abstracts

Track: 01 Cancer Pharmacology

Cancer pharmaceuticals play an important role in drug development. To keep up with the changing face of drug discovery, cancer pharmacology in both the lab and the hospital has had to adapt using experimental models and target-based approaches. It also conducts research in the disciplines of cellular carcinogenesis, biochemistry, radiation biology, and clinical pharmacology in order to develop medical help methods. It also promotes science. Both medications' pharmacological and oncological properties are frequently evaluated.

Gene Expression
Oncogenesis
Signal transduction
Protein purification
Site-directed mutagenesis

Cancers are fundamentally genetic disorders, produced by mutations that lead to aberrant cell proliferation, whether they originate by accident, environmental circumstances, or inherited predisposition. From the search for cancer-related genes to improvements in precision medicine, Researchers learning more about cancer's genetics and genomes and applying what they learned to develop new treatment options.

Challenges in Cancer Genomics Research
Opportunities in Cancer Genomics Research
Characterizing Cancer Genomes
Analyzing Standard of care
Relating Inherited Risk Factors to cancer genomics

Researchers have been looking for ways to exploit a promising concept for more than a century: that a person's immune system is fundamentally capable of responding to cancer and may be harnessed to effectively guard against it. Recent advances have pushed this concept into clinical reality, and they continuing to advance immune-based medicines to revolutionize cancer care.

Creative Biolabs
The Antigen Formulation
The Choice of the Adjuvant
The Choice of Delivery Systems
Immunotherapy Strategies

Cancer metabolism is the difference between cancer cells and most normal tissue cells in terms of cellular metabolism pathways. Aerobic glycolysis, decreased oxidative phosphorylation, and enhanced synthesis of biosynthetic intermediates required for cell growth and proliferation are just a few of the metabolic changes seen in cancer cells.
One method of destroying cancer cells is to starve them to death by giving them nutrition, particularly glucose. Researchers believe that figuring out how cancer cells get and utilise fuel will lead to the creation of novel medicines. The link between fat and cancer, as well as how the body's metabolism may promote tumour growth, are also being studied.

Cancer and Glucose Metabolism
Lethal Energetic Stress
Biochemical Signaling
Cellular Metabolism Pathway
Tumour growth

Modulation of signaling pathways impacts cells' ability to respond effectively to extracellular inputs. Cell-to-cell signaling can be influenced by affecting the quantity and/or activity of functional receptors on their surfaces.

Cell growth and other cellular functions are regulated by a complicated network of signals. Many diseases, including cancer, can develop when this communication system goes awry and messages aren't effectively delivered or processed. Experts in molecular, cellular, structural, and developmental biology are among the cell signalling and regulatory researchers.

Dysregulated signaling in cancer
Oncogenic mutation
Exploring the complex signaling circuits
Deciphering Cancer
Tumor Immunology

Chemical biology is the study and manipulation of biological systems using chemical instruments. Small compounds are designed and deployed by our experts to examine and target certain cellular processes, either blocking or enhancing the actions of proteins and other molecules. This allows us to better understand these pathways and establish the framework for the development of disease-slowing or disease-reversing medications.

The processes by which a fertilised egg's single cell grows and develops into a mature animal are studied in developmental biology. Scientists employ a variety of experimental approaches to learn about the genetic cues that lead cells to differentiate into specialised tissues and organs, how this process influences regeneration and ageing, and how cancer is caused by disturbance of normal development.

Cancer Dependencies
Cancer drug design
Angiogenesis
Cell proliferation and cell death
Tumor initiating cells

Computational Oncology is a broad phrase that refers to any computer-based modeling of tumour biology and cancer treatment. In order to optimize treatment, mathematical modeling is often utilized to research the pharmacokinetics and pharmacodynamics interactions of obtainable anticancer drugs.

Scientists have been able to acquire an incredible quantity of data about the genomes of both normal and malignant cells because to next-generation sequencing. Researchers are developing tools that will allow them to navigate and interpret this massive amount of data, as well as translate molecular findings into medicines that will assist patients, through computational oncology.

Clinical Big data
Computational Argumentation
Patient generation Electronic Data
Molecular findings
Pharmacodynamics

Imaging is a technique for creating images of the inside of your body. It can aid in the detection of cancers and other abnormalities, as well as determining the extent of disease and determining if treatment is effective. Biopsies and other surgical procedures may also be performed using imaging.

The use of imaging tools such as PET/CT, MRI, and live microscopy to watch and evaluate biological processes over time has been pioneered by researchers. They employ these technologies to enhance laboratory investigations into the root causes of cancer and to develop creative techniques to improve detection and treatment by emphasising living cells or tissues with specialised chemicals.

Computed tomography
Magnetic resonance imaging scan
Breast MRI
X-rays and other radiographic tests
Mammography

Cancer immunology is an interdisciplinary discipline of biology concerned with studying the role of the system in cancer progression and development; the foremost well-known application is cancer immunotherapy, which employs the system as a cancer treatment.

The system is formed from a complicated network of cells and chemicals that employment together to stay disease at away. Many components of this network are being investigated by researchers, including cellular responses, antigen processing, cancer immunology, infection and immunity, and cell-based therapies, with the target of discovering effective novel cancer and other illness treatments.

T cell activation and regulations
Mechanisms of tumor resistance
T cell tolerance and performance
Inflammation and tumor immunology
Immunology receptor signaling

Cancer stem cells are cancer cells (found in tumours or haematological malignancies) that have features similar to normal stem cells, such as the ability to produce all cell types observed in a cancer sample. In contrast to other non-tumorigenic cancer cells, CSCs are tumorigenic (may cause tumours).

The field of stem cell research is filled with possibilities for medical advancement. Researchers are exploring the use of embryonic or induced pluripotent stem cells in the development of medicines and disease models. They also look at fundamental concepts like stem-cell pluripotency and self-renewal, as well as stem cells in the context of both normal and malignant development.

Cancer stem cell markers
Cancer stem cell transcription factors
Epithelial to Mesenchymal Transition
Induced Pluripotent stem cells
Malignant Development

Scientists understand the atomic configuration of molecules using techniques like x-ray crystallography and super-resolution optics to shed light on the smallest elements of life and disease. Structural biology is critical for understanding how genes and proteins work and provides crucial information for developing more effective cancer therapeutics.

Mathematics, computer science, and biology are all used in systems biology to gain a global understanding of how the components of complex living systems interact and function. It's an important aspect of everything we do at Memorial Sloan Kettering, from developing new cancer medicines to studying the cancer genome, immune system, Microbiome, and other topics.

Structural and Biophysical Biology
Molecular Application
Bioinformatics
Data science
Bioengineering and Biotechnology

Cancer treatment that targets proteins that affect how cancer cells grow, divide, and disseminate is known as targeted therapy. Precision medicine is built on this foundation. Researchers are better able to build medicines that target the DNA alterations and proteins that drive cancer as they learn more about them.

Precision treatment, which takes advantage of information about the genes and proteins altered in a person's cancer, includes targeted medicines. Experts are developing new techniques to impede cancer cells' capacity to proliferate, survive, and spread by devising medications that interfere with specific chemicals in cancer cells while inflicting minimal harm to normal cells and tissues.

Hormone therapies
Signal transduction inhibitors
Gene expression modulators
Apoptosis inducers
Monoclonal antibodies

Oncology nursing care is defined as providing for oncology patients requirements throughout their disease, including appropriate screenings and other preventative efforts, symptom management, care to maintain as much normal function as feasible, and supporting measures at the end of life.

Symptoms and side effects of cancer
Psychological support for individuals and families
Prevention, both primary and secondary
Cancer treatments' long-term impacts

Cell therapy is a treatment in which living cells are injected, grafted, or implanted into a patient to achieve a therapeutic effect, such as by grafting stem cells to regenerate diseased tissues or transplanting T-cells capable of fighting cancer cells via cell-mediated immunity during immunotherapy.

Cell-based treatment is a growing scientific field that involves altering a patient's own cells or cells from a donor to combat disease and treat medical ailments. Researchers have recently assisted in the development of a breakthrough cell-based strategy to treating blood malignancies known as chimeric antigen receptor therapy. They're still looking into a variety of cell types for potential medicinal applications.

Somatic cell technologies
Cell immortalization technologies
Genome Editing technology
Cell plasticity technologies
Three-dimensional technologies

Epidemiology is a tool for determining whether diseases or injuries are caused by particular factors. Patients are evaluated as a whole in epidemiology, where communities are viewed as patients. Epidemiology is a scientific, methodical, and data-driven investigation of the distribution and determinants (causes, risk factors) of health-related states and events (not just diseases) in defined populations.

By combining epidemiology, statistics, and outcomes research, we are able to better understand cancer's causes while also developing better methods for diagnosing, treating, and preventing the disease. Research studies on cancer risk, care delivery, and how to improve clinical research benefit from the expertise of multidisciplinary teams.

Cancer epidemiology and prevention
Breast cancer epidemiology statistics
Lung cancer epidemiology statistics
Principles and method for cancer epidemiology

Any substance that affects the function of the heart and blood arteries is referred to as a cardiovascular drug. Drugs that affect the cardiovascular system are some of the most commonly prescribed in medicine. Hypertension (high blood pressure), angina pectoris (chest pain caused by insufficient blood flow through the coronary arteries to the heart muscle), heart failure (inadequate output of the heart muscle in comparison to the needs of the rest of the body), and arrhythmias are all disorders in which such drugs may be beneficial (disturbances of cardiac rhythm).

New drug development
Physiological and pharmacological of drug actions
Metabolism
Drug Interactions and side effects
Clinical results with new established agents

Clinical pharmacology is concerned with all aspects of the drug-human interaction. It is the NHS's only medical specialty dedicated to the safe, effective, and cost-effective use of medications. It is a broad field that simultaneously maintains and promotes the highest standards of healthcare.

Clinical pharmacologists have medical and scientific knowledge that allows them to assess evidence and generate new information through well-designed investigations. Clinical pharmacologists must have enough outpatients to supply clinical treatment, teach and educate, and conduct research, also as be overseen by medical professionals.

Principles of Pharmacokinetics
Clinical Pharmacology and therapy
Drugs to treat Myocardial Infections
Treatment of peptic ulcer
Treatment of hypertension

Immunopharmacology is a branch of medicine that combines immunology and pharmacology. Drugs that impact the immune system, whether to suppress, activate, or alter it in any way, are the subject of this study and medical science specialisation. Anti-rejection medicines and vaccines are two of the most well-known immunopharmacology therapies.

Immunopharmacology can target any of these diverse categories to develop new treatments and drugs to help treat disease, or simply to advance scientific knowledge in the subject.

Cytokine
Immunotoxicology
Abatacept
Vaccine Efficacy
Autoimmune Disease

Biochemistry, cell biology, physiology, chemical biology, and biomedicine all contribute to molecular pharmacology, which is a multidisciplinary science. The focus is on the effects of medications on target molecules. It can be paired with studies in systems pharmacology, which looks at the positive and negative effects of specific medications on bodily systems, or toxicology, which looks at the harmful effects of pharmaceuticals and other substances on the body.

Biochemical pharmacology studies intact animals, organs, cells, subcellular compartments, and individual protein molecules to define the mechanisms of drug action and how drugs influence the organism using biochemistry, biophysics, molecular biology, and cell physiology.

Molecular Signaling
Mechanism of Drug Action
Chemical Biology
Drug Discovery
Structure of Drug-Receptor Complex
Systems Analysis of Drug Action
Drug Transport

The Department of Pharmacology has a great focus on neuroscience research. Researchers in the department study the fundamental pharmacology of neurotransmission, how investigational pharmaceuticals affect it, and how drugs can be used to treat brain diseases more effectively.

The Department of Pharmacology studies drugs for addiction and substance abuse disorders, epilepsy and anticonvulsants, learning and memory mechanisms, the impact of the blood brain barrier on disease and neuroactive medication penetration, and the causes of chronic pain and analgesics.

Auditory Cognitive Neuroscience
Autonomic Neuroscience
Brain Imaging Methods
Decision Neuroscience
Gut-Brain Axis
Neural Technology
Neurodegeneration
Neurodevelopment

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